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Futurity (September 15, 2023) Brain Organoids Could Reveal Origins of Autism
With organoids, and with a new method for modifying genes within these organoids using the CRISPR-Cas gene scissors, the researchers found out which genetic networks in which cell types in the brain are responsible for the development of autism. “Our model offers unparalleled insight into one of the most complex disorders affecting the human brain and brings some much needed hope to clinical autism research,” says Jürgen Knoblich, professor and scientific director of the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences in Vienna and coauthor of the study in Nature.
PharmTech (September 15, 2023) CPHI Annual Report Predicts AI Transformation of All Drug Development Processes by 2026
A recent publishing of the first part of the CPHI Annual Report predicts substantial progress ahead for artificial intelligence (AI)’s use in pharma, despite the uproar surrounding ChatGPT and other AI programs. According to a press release, the implications go to the extent that within the next 10 years, more than 50% of approved drugs will involve AI in their development and/or manufacturing. The findings come ahead of CPHI Barcelona held at Fira Barcelona from Oct. 24–26, 2023. The report features insights from 250 global pharma companies and is seen as a key indicator of the industry’s future growth prospects, according to the press release. This year is the first time in the report’s history that pharmaceutical “AI companies” (26%) have overtaken “late stage” (20%) and “early stage” (19%) biotechs as the industry’s most appealing investment option.
MedicalExpress (September 12, 2023) A 3-D bioprinted tumor-on-a-chip model
In a new study published in Scientific Reports, Nafiseh Moghimi and a team of researchers in applied mathematics at the University of Waterloo Canada, medicine and engineering at the Harvard Medical School and the Brigham and Women’s Hospital U.S., and medical genetics at the Yeditepe University Turkey, bioengineered bioprinted in vitro models of a breast cancer tumor microenvironment made of co-cultured cells mixed in a hydrogel matrix. The well-regulated architecture facilitated the development of model tumor heterogeneity.
News Medical & Life Sciences (September 12, 2023) Human post-implantation embryo models show promise in unraveling early development
A recent Nature study evaluates post-implantation development in humans using embryo-like models based on genetically unmodified human naïve embryonic stem cells (ESCs).
Genetic Engineering & Biotechnology News (September 13, 2023) Single-Cell Organoid Screens Illuminate Autism Genetics
Researchers at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, and at ETH Zurich have developed a novel single-cell brain organoid screening system to help identify the gene mutations, vulnerable cell types, and gene regulatory networks that underlie autism spectrum disorders (ASDs). The new system, called CRISPR–human organoids–single-cell RNA sequencing (CHOOSE), combines brain organoid technology with CRISPR-based genetic targeting, allowing scientists to comprehensively test the effects of multiple mutations in parallel, at a single-cell level within human brain organoids.
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