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Drug Target Review (10/20/2023) New 3D tumour models simulate complex tumours
Scientists from University of Waterloo have created a method which produces better three-dimensional (3D) models of complex cancers. The team combined innovative bioprinting techniques with synthetic structures or microfluidic chips which will enable lab researchers to more accurately understand heterogeneous tumours – tumours with more than one kind of cancer cell, often dispersed in unpredictable patterns.
Imaging Technology News (10/19/2023) Human Lung Chip Leveraged to Faithfully Model Radiation-induced Lung Injury
Human life-like in vitro model of radiation damage sustained to the lung opens an unprecedented window into the early disease process, and opportunities for drug development.
News Medical & Life Sciences (10/18/2023) Lung chip model offers new insights into how radiation damages the lungs
A multi-disciplinary research team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston Children’s Hospital led by Wyss Founding Director Donald Ingber, M.D., Ph.D., in an FDA-funded project, has developed a human in vitro model that closely mimics the complexities of RILI and radiation dose sensitivity of the human lung.
Medical Xpress (10/18/2023) iPSC-derived kidney organoids to model a lifelong renal disease
Researchers have generated induced pluripotent stem cell (iPSC)-derived kidney organoids to model Alport syndrome caused by a mutation in the COL4A5 gene and have demonstrated the utility of a chemical chaperone to rescue the protein misfolding and collagen misassembling caused by the mutation. The research is published in the journal Communications Biology.
Technology (10/17/2023) Networks How AI-Powered Cell Culture Could Revolutionize Drug Discovery
Scientists have not embraced 3D models of human organs. AI could change that.
Science Daily (10/17/2023) Human Lung Chip leveraged to faithfully model radiation-induced lung injury
Wyss researchers have developed a human in vitro model that closely mimics the complexities of radiation-induced lung injury (RILI) and radiation dose sensitivity of the human lung.
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