Home Forums *News Top Industry News January 27 — February 2

Top Industry News January 27 — February 2

Home Forums *News Top Industry News January 27 — February 2

    • Lauren Feldman

      Medical Xpress (February 2, 2024) ‘Heart-on-a-chip’ to test chemotherapies and other cancer drugs for heart toxicity

      Chemotherapy can be toxic to heart cells. To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional “heart-on-a-chip” to evaluate drug safety. In a study published in the journal Lab on a Chip, they show that the heart-on-a-chip, created using stem cells, accurately predicts the effects of drugs on human heart cells.

       

      Medical Xpress (February 1, 2024) Researchers use the eye as a window to study liver health

      Researchers at Karolinska Institutet have developed a method to study liver function and disease without requiring invasive procedures. After transplanting liver cells into the eye of mice, the cornea can be used as a window into the body to monitor liver health over time. The study is published in the journal Nature Communications.

       

      Popular Mechanics (January 31, 2024) Scientists Are About to Break the Blood-Brain Barrier—and Maybe Transform Medicine

      Advanced tech could soon breach the body’s most protected organ, heralding a new era in treatment.

       

      Vox (January 31, 2024) The US uses endangered monkeys to test drugs. This law could free them.

      Biomedical industry demand for long-tailed macaques is so high that, analysts reported last year, a single animal could be sold for as much as $60,000. On arrival at pharmaceutical companies and research institutions, they’re destined to live in cages and face experimentation to test everything from the weight-loss drug Ozempic to Covid-19 vaccines. US scientists have been using large numbers of these monkeys since the 1970s, when India halted exports of rhesus macaques, and researchers had to find a new, more easily replaceable species for lethal pharmaceutical testing. Long-tailed macaques’ relative abundance in the wild meant they fit the bill. Unfortunately, they’re not so abundant in the wild anymore. Last April, amid growing concerns about the species, a coalition of animal rights activists, conservation groups, and scientists led by People for the Ethical Treatment of Animals (PETA) petitioned the federal government to list the long-tailed macaque under the Endangered Species Act.

       

      ScienceAlert (January 31, 2024) This Tiny Version of a Human Heart on a Chip Beats Like The Real Thing

      Simulating miniaturized versions of human organs in the lab is an emerging tool in medical research, and researchers now have a new ‘heart-on-a-chip’ model to make use of. The team behind the chip, from Cedars-Sinai Medical Center in Los Angeles, says that it will have an important role to play in testing the safety of cancer treatments, which have been shown to risk heart damage while fighting cancer cells. Noteworthy upgrades over previous heart-chip models include the maturity of the cells that the team developed from human induced pluripotent stem cells (hiPSCs), and its ability to beat much like a human heart – at around 60 beats per minute.

       

      The Scientist (January 29, 2024) Researchers CHOOSE Organoids to Investigate Neurodevelopment

      A 3D variation of pooled CRISPR screens could connect the dots between autism spectrum disorder genetics and cell fate pathways in the developing brain.

       

      Fortune (January 27, 2024) Why Big Pharma can’t quit the lab monkey business

      Can Big Pharma produce the medicines and treatments America needs without the long-tailed macaque?

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