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Fierce Biotech Parexel picks pact with Partex to leverage AI for trials, drug development (August 17, 2023)
Parexel, a global CRO, will collaborate with digital pharma platform provider Partex to leverage AI in pursuit of drug discovery and development of biotech as well as to streamline clinical trials.
Science News Explores Stem cells can help build lab-grown organs that mimic real life (August 16, 2023)
Stem cells can change into any of many different specialized cells. One type of stem cell is proving useful in making organoids. Known as human pluripotent stem cells, these start out as normal body cells. Scientists then reset them to a very early stage of development. That allows these cells to mature all over again, now into any type of needed cell. “It just blew my mind that you can take [pluripotent stem cells] and turn them into anything,” Smith says.
Genetic Engineering & Biotechnology News Humanized Animal Models Boost Translational Value (August 15, 2023)
Due to advancements in genetic engineering, small animal models are continuing to change in response to market needs. Model developers strive to better reflect the role of this important asset in both research and translational science through increased humanization of specific genes. Immuno-oncology, biologic drugs, and cell and gene therapies are some of the most important drivers of the humanization trend. As these models incorporate more human traits, they facilitate therapeutic drug development and provide more human-like responses. This in turn drives the market to request even more complex models, solidifying the humanization trend. GEN speaks with five leading small animal model developers to learn more about how they are responding to the market and regulatory forces.
Fierce Biotech Are ‘living fillings’ the future of teeth restoration? Enamel-growing organoids could open up regenerative dentistry (August 15, 2023)
It’s one of life’s hard truths: Once tooth enamel is gone, you can’t get it back. And while tooth tech has come a long way since the days of wooden dentures, there’s no regrowing lost teeth. But that may not be the case forever. In a new study published Aug. 14 in Development Cell, a research team led by scientists from the University of Washington School of Dentistry described how it used human stem cells to grow organoids, or 3D tissue cultures, that produce working enamel-producing ameloblasts.
The Scientist Turning Organoids Inside Out (August 15, 2023)
Recently, Julia Co and her colleagues published a paper that describes a rapid method to reverse the polarity of human gastrointestinal organoids.5 Through this protocol, researchers formed “apical-out” organoids, where the apical surface faces outwards towards the culture medium and is accessible for scientists to study epithelial barrier integrity, secretion, absorption, innate immune responses, and differentiation. To change organoid polarity, researchers first grow basolateral-out organoids and release them into suspension by depolymerizing the ECM proteins. As the organoids are no longer in contact with the ECM, their polarity becomes reversed. Scientists confirm this change to the apical-out morphology by immunostaining proteins with polarized distributions, such as labeling zonula occludens-1 for the apical tight junctions and β-catenin for the basolateral adherens junctions.
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