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Hi All,
As I’m sure you already know, we’re working in a fast-evolving field, one in which new model systems and new findings are announced on a near-daily basis. As a community, we appreciate the importance of going beyond 2D cell culture by embracing 3D model systems. Some of us work with organoids and multicellular tumor-spheroids, others are focused on engineering 3D hydrogel culture models, and still many others are developing or implementing Organ-Chips. Each of these systems have specific advantages and can be used to derive unique insights into disease pathology, tissue biology, drug pharmacology, and so on.
However, it can be difficult to keep up with the fast pace of research in these related systems. As such, cross communication between labs using different models is limited. We believe that there is significant benefit in information sharing across models – afterall, you never know when inspiration will strike.
To help you keep up with the 3D culture community, we’ll be publishing a partial roundup of relevant research each week. Try as we might, it will be difficult to provide a comprehensive list – there is, afterall, a lot out there. But, we hope that these roundups will spark interest, conversations, and ultimately strengthen the bonds within our community.
If we’ve missed an article, please don’t be shy – post it here for others to see (what better time to promote your recent paper?!)
So, in that vein, here is the first roundup, featuring article from the past two weeks. We’ll also be posting tissue-specific articles in their relevant subtopic within Moxi.
Organ-Chips and MPS
- Conversation before crossing: dissecting metastatic tumor-vascular interactions in microphysiological systems
- Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
- Digital Light Processing (DLP)-based 3D printing for microphysiological systems applications
- Modeling human HSV infection via a vascularized immune-competent skin-on-chip platform
- Development of a microfluidic platform to emulate the human microvasculature
- Modeling ascending Ureaplasma parvum infection through the female reproductive tract using vagina-cervix-decidua-organ-on-a-chip and feto-maternal interface-organ-on-a-chip
- Nanofiber self-consistent additive manufacturing process for 3D microfluidics
- Development of synthetic vasculature, 4D optical oxygen mapping and their implementation in human 3D liver tissue models
- IND04-01 Modernizing drug discovery & development with organ-chip technology
- Selective plane illumination microscope dedicated to volumetric imaging in microfluidic chambers
- 3D skin models along with skin-on-a-chip systems: A critical review
- A human in vitro model for airway neuro-effector interactions
- One small step in time, one giant leap for DMPK kind – A CRO perspective of the evolving core discipline of drug development
- Human liver microphysiological system for predicting the drug-induced liver toxicity of differing drug modalities
Organoids, MCTS, and 3D Suspension Cultures
- Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models
- [Expression, purification, and characterization of cell-permeable fusion antioxidant enzyme sensitive to matrix metalloproteinases-2/9].
- A Three-Dimensional Organoid Culture System to Model Invasive Patterns of Patient-Derived Glioma Stem Cells
- Micromanipulator-Assisted Subretinal Transplantation of Human Photoreceptor Reporter Cell Suspensions into Mice
- Modelling adult stem cells and their niche in health and disease with epithelial organoids
- From organoids to bedside: advances in modeling, decoding and targeting of colorectal cancer.
- In-depth analysis of the relationship between bovine intestinal organoids and enteroids based on morphology and transcriptome
- Long-Term Expansion of Murine Primary Hepatocyte Organoids
- Development And Application Of Patient-Derived Glioblastoma Organoids For Studying Tumor Heterogeneity And The Immune-Related Microenvironment
- Neuroregenerative potential of SCAP-derived neuronal cell spheroids regulated by SCAPs under various microenvironments in a pulp-on-chip system
- Correlation of the regenerative potential of dermal fibroblasts in 2D culture with the biological properties of fibroblast-derived tissue spheroids
- Development of human retinal organoid models for bisphenol toxicity assessment
- Micro- and nanodevices for integration with human brain organoids
- A benchtop brain injury model using resected donor tissue from patients with Chiari malformation
- Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis
- Non-destructive platform for morphologic and cell density characterization of developing and drugged multicellular tumor spheroids
- Understanding 3D culture in smooth muscle cell biology and the modelling of atherosclerosis
- Composite Multicellular Spheroids Containing Fibers with Pores and Epigallocatechin Gallate (EGCG) Coating on the Surface for Enhanced Proliferation of Stem Cells.
- Development of a novel in vitro model of the cornea to investigate cell dynamics within the mammalian limbal niche
- Determination of 5-Fluorouracil and Doxorubicin Concentrations Required for Effective Induction of Cytotoxicity and Morphological Responses in 3D Tumor Spheroids
- Generation of Tissue Spheroids via a 3D Printed Stamp-Like Device
- Balance between the cell viability and death in 3D
- Wnt-Activating Human Skin Organoid Model of Atopic Dermatitis Induced by Staphylococcus aureus and Its Protective Effects by Cutibacterium acnes
- Advantages of CRISPR-Cas9 combined organoid model in the study of congenital nervous system malformations
- Development and validation of a 3D pancreatic cancer cell organoid system for radiation response studies to support advanced radiotherapy
- Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms
- The impact of antidepressants on human neurodevelopment: Brain organoids as experimental tools
- Harnessing preclinical models for the interrogation of ovarian cancer
- Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
- Analyzing the Morphology of Three-Dimensional Tissue Models using Deep Learning
- Building a tissue: mesenchymal and epithelial cell spheroids’ mechanical properties at micro- and nanoscale
- Development, characterization and application of luminescent human iPSC-derived neurospheroids in ischemic stroke research
Hydrogels and biomaterial scaffolds
- Three-dimensional (3D) printing of hydroxyapatite-based scaffolds: A review
- 3D-printed PLA/Gel hybrid in liver tissue engineering: Effects of architecture on biological functions
- Hydrogel based 3D printing: Bio ink for tissue engineering
- A Multifunctional 3D Bioprinting System for Construction of Complex Tissue Structure Scaffolds: Design and Application
- Applications and Limitations of 3D Bioprinters in Tissue Culturing: A Review
- Biodegradable and Electrically Conductive Melanin-Poly (3-Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications
- 3D-Printed Porous Metallic Scaffold For Maxillofacial Bone Reconstruction.
- Open-source library of tissue engineering scaffolds
- Extracellular Matrix Profiling and Disease Modelling in Engineered Vascular Smooth Muscle Cell Tissues
- Ethical challenges with 3D bioprinted tissues and organs
- Micropatterned Hydrogels with Highly Ordered Cellulose Nanocrystals for Visually Monitoring Cardiomyocytes
- Biofabrication of a flexible and conductive 3D polymeric scaffold for neural tissue engineering applications; physical, chemical, mechanical, and biological evaluations
- Evaluation of Skin Irritation of Acids Commonly Used in Cleaners in 3D-Reconstructed Human Epidermis Model, KeraSkinTM
- Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine
- Engineered Biomaterials to Guide Spheroid Formation, Function, and Fabrication into 3D Tissue Constructs
Miscellaneous but no less relevant
- Modeling drug-induced liver injury: current status and future prospects
- 3D engineered tissue models for studying human-specific infectious viral diseases
- Glioblastoma Multiforme: A Review
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