3D Culture Models and Hot Off The Press Research 10-14-2022

[Stephen Riffle]

Hi All,

Here again with another research roundup. Based on some feedback and the volume of studies coming out, I’m going to be curating this list to reduce the overall number but, hopefully, enriching it for interesting content. Admittedly the selection is largely based on titles and abstracts, so if I’ve missed a cool article, please drop it in the comments below!

(Also, you’ll see this text throughout Moxi as I divide these papers up into their respective tissue Topics. Sorry in advance for the repetition.)

And with that, on to the list:

Organ-Chips and MPS

• Tissue clearing of human iPSC-derived organ-chips enables high resolution imaging and analysis
• Effect of probiotics on wound healing in a 3D bioprinted human mucosa model
• Mechanoresponsive regulation of fibroblast-to-myofibroblast transition in three-dimensional tissue analogues: mechanical strain amplitude dependency of fibrosis
• Lung-on-a-Chip and Lung organoid models

Organoids, MCTS, and 3D Suspension Cultures

• Systematic review on spheroids from adipose‐derived stem cells: Spontaneous or artefact state?
• Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis
• TWEAK-Fn14-RelB signaling cascade promotes stem cell-like features that contribute to post-chemotherapy ovarian cancer relapse
• Stem cell microencapsulation maintains stemness in inflammatory microenvironment
• Detection of Heterogeneous Cells in Cell Spheroids by Applying High-Frequency Second-Order Sensitivity Matrix Electrical Impedance Tomography (HSSM-EIT)
• Spontaneous Cell Cluster Formation in Human iPSC-Derived Neuronal Spheroid Networks Influences Network Activity
• Generation of murine tumour-reactive T cells by co-culturing murine pancreatic cancer organoids and peripheral blood lymphocytes
• The Development and Application of Open-Source 3D Bioprinted Organoid and Tumoroid Models for Translational Sciences
• D-CryptO: deep learning-based analysis of colon organoid morphology from brightfield images
• An integrated organoid omics map extends modeling potential of kidney disease
• The pivotal application of patient-derived organoid biobanks for personalized treatment of gastrointestinal cancers
• Quantum Dots Mediated Imaging and Phototherapy in Cancer Spheroid Models: State of the Art and Perspectives
• AGENT-BASED MODELING PREDICTS RAC1 IS CRITICAL FOR OVARIAN CANCER METASTASIS
• Extracellular vesicles derived from human dermal fibroblast effectively ameliorate skin photoaging via miRNA-22-5p-GDF11 axis
• Survivin Regulates Intracellular Stiffness and Extracellular Matrix Production in Vascular Smooth Muscle Cells

Hydrogels and biomaterial scaffolds

• 3D cell/scaffold model based on aligned-electrospun-nanofiber film/hydrogel multilayers for construction of anisotropic engineered tissue
• Alginate-based bioink for organoid 3D bioprinting: A review
• HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering
• 3D bioprinted extracellular vesicles for tissue engineering – a perspective

Miscellaneous but no less relevant

• Approaches to benchmark and characterize in vitro human model systems
• In vitro models to evaluate ingestible devices
• Chapter 7 – Human models as new tools for drug development and precision medicine

[Author]

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