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Christopher Carman

The cells in the chip have all been extensively characterized in terms of function (e.g., barrier properties, mucin production), morphology (e.g., mature brush boarder with well differentiated microvilli and tight junctions) , multi-lineage epithelial cell subtype formation at expected ratios and transcriptome. All of these properties closely align with what is observed in human tissue. Much of the characterization can be found in our following publication: <span lang=”EN-US” xml:lang=”EN-US” data-scheme-color=”@F4F4F4,2,18:20000,19:80000″ data-usefontface=”true” data-contrast=”none”>Apostolou A</span><span lang=”EN-US” xml:lang=”EN-US” data-scheme-color=”@F4F4F4,2,18:20000,19:80000″ data-usefontface=”true” data-contrast=”none”>, et.al, Cell Mol Gastroenterol Hepatol. 2021;12(5):1719-41.</span>