Home Forums Reproductive Ask Me Anything: I created a Vagina-on-a-Chip Reply To: Ask Me Anything: I created a Vagina-on-a-Chip

Gautam Mahajan

Thank you everyone for submitting their questions.

Reply to @Sasha.. Great Questions:

1. The main focus of the paper is to model host-microbiome interactions and this model can be used to study infection and progression of STI for example gonorrhoea, chlamydia etc. I feel the workflow in the manuscript can be used for these applications with some optimization.

2. In figure 1, we showed that Vagina Chip is responsive to fluctuations to hormone levels. Although Menopause is a complex phenomenon, the chip can help recapitulate the changes to vaginal epithelium, stroma and microbes due to hormonal changes during menopause.