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Lorna Ewart

This is a great question John!

I recently read a paper in Frontiers in Bioengineering and Biotechnology that describes the creation of a murine bone marrow microenvironment (https://www.frontiersin.org/articles/10.3389/fbioe.2022.855777/full).  The authors were able to maintain functional hematopoietic stem cells in vitro over a 14 day culture period.  The chip recapitulated cell-cell interactions that occur in vivo and open the opportunity for mechanistic investigation of hematologic malignancies. But in response to your question, the authors agree.  They end the paper stating that their chip demonstrated that it can be used to validate cellular phenotypes found within in vivo murine leukemic models and proposed that the in vitro environment of a similar human chip model will recreate human in vivo.